HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 6-(Bromomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | (2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methanol | HCID 13345225 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-(Bromomethyl)pyrido[3,2-d]pyrimidine-2,4-diamine | HCID 13345226 | — |
Reaction Steps
A suspension of 0.72 g (3.77 mmol) of 6 in 12 mL dry THF was stirred for 8 hours with 1 mL of phosphorus tribromide. The precipitated solid was filtered, washed with cold 50% THF-Ether, and dried to give 7. Because of the instability, this compound was not purified further. The 1HNMR showed that the majority of the solid was the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114339 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-88aeee078fc04165a1649980b2d8b6d0 |
| Source note | uspto-grants-2000_09 |