Lawesson's reagent → HCID 23300104, compound

HRID 1952790Notes

Reaction equation

HRID 1952790 reaction equation
[C:1]1([C:7]2[C:8](=O)[NH:9][C:10]3[C:15]([C:16]=2[C:17]([O:19][CH:20]([CH3:22])[CH3:21])=[O:18])=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:33])=CC=1>>[C:1]1([C:7]2[C:8](=[S:33])[NH:9][C:10]3[C:15]([C:16]=2[C:17]([O:19][CH:20]([CH3:22])[CH3:21])=[O:18])=[CH:14][CH:13]=[CH:12][CH:11]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 87949Lawesson's reagentHCID 15389090HCID 15389090, compound

Product 1

HCID 23300104HCID 23300104, compound

Procedure

307 mg (1 mmol) of isopropyl 3-phenylquinolin-2(1H)-one-4-carboxylate (Example 7) are reacted with Lawesson's reagent according to the process described in Example 5 and purified by chromatography on silica gel as indicated above (mobile phase: n-heptane/ethyl acetate=411).

Workup

  1. custompurified by chromatography on silica gel as indicated above (mobile phase: n-heptane/ethyl acetate=411)

Sources & evidence

ORD record
ord-d94198792b2443099f7d0a41167c5284
Source dataset
uspto-grants-2000_09
Patent number
US06114349

Reaction notes

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