反应详情

Triethylamine (6.50 ml) and octadecyl isocyanate (14.40 ml) were added to a solution of the syrup containing 2-(hydroxymethyl)phenyl 4-methylpiperazinyl ketone (9.83 g) in dichloromethane (100 ml). After being stirred for 14.5 hours at room temperature, the insoluble material was filtrated out under a vacuum. The filtrate was concentrated. The residue was purified by silica gel column chromatography (silica gel 225 g, chloroform:methanol=80:1), thereby yielding 12.00 g of the aimed compound as white solid.

1. filtrationthe insoluble material was filtrated out under a vacuum
2. concentrationThe filtrate was concentrated
3. customThe residue was purified by silica gel column chromatography (silica gel 225 g, chloroform:methanol=80:1)