Triethylamine → [[2-[(4-Methylpiperazinyl)carbonyl]phenyl]methoxy]-N-octadecylformamide

HRID 1952814ノート

反応式

HRID 1952814 の反応式
C(N(CC)CC)C.[CH2:8]([N:26]=[C:27]=[O:28])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25].[CH3:29][N:30]1[CH2:35][CH2:34][N:33]([C:36]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=2[CH2:44][OH:45])=[O:37])[CH2:32][CH2:31]1>ClCCl>[CH3:29][N:30]1[CH2:31][CH2:32][N:33]([C:36]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][C:39]=2[CH2:44][O:45][N:26]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[CH:27]=[O:28])=[O:37])[CH2:34][CH2:35]1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 66988Octadecyl isocyanateHCID 232993442-(Hydroxymethyl)phenyl 4-methylpiperazinyl ketone

生成物 1

HCID 54255245[[2-[(4-Methylpiperazinyl)carbonyl]phenyl]methoxy]-N-octadecylformamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Triethylamine (6.50 ml) and octadecyl isocyanate (14.40 ml) were added to a solution of the syrup containing 2-(hydroxymethyl)phenyl 4-methylpiperazinyl ketone (9.83 g) in dichloromethane (100 ml). After being stirred for 14.5 hours at room temperature, the insoluble material was filtrated out under a vacuum. The filtrate was concentrated. The residue was purified by silica gel column chromatography (silica gel 225 g, chloroform:methanol=80:1), thereby yielding 12.00 g of the aimed compound as white solid.

後処理

  1. filtrationthe insoluble material was filtrated out under a vacuum
  2. concentrationThe filtrate was concentrated
  3. customThe residue was purified by silica gel column chromatography (silica gel 225 g, chloroform:methanol=80:1)

出典と根拠

ORDレコード
ord-6a2a5ca01348482ca2ba2778a554984b
出典データセット
uspto-grants-2000_09
特許番号
US06114325

反応ノート

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