反应详情

4N Hydrochloric acid--ethyl acetate solution (8.50 ml) was added to a solution of [[2-[(4-methylpiperazinyl)carbonyl]phenyl]methoxy]-N-octadecylformamide (11.98 g) in ethyl acetate (120 ml) while being cooled with ice. After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized from ethyl acetate-ethanol mixed solvent, thereby yielding 12.12 g of the aimed compound as white solid.

1. temperaturewhile being cooled with ice
2. concentrationthe reaction mixture was concentrated
3. customThe residue was recrystallized from ethyl acetate-ethanol mixed solvent