Hydrochloric Acid → HCID 86755725、化合物

HRID 1952815ノート

反応式

HRID 1952815 の反応式
[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][O:18][N:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[CH:20]=[O:21])=[O:10])[CH2:5][CH2:4]1>C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]1[CH2:4][CH2:5][N:6]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[CH2:17][O:18][N:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[CH:20]=[O:21])=[O:10])[CH2:7][CH2:8]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 54255245[[2-[(4-Methylpiperazinyl)carbonyl]phenyl]methoxy]-N-octadecylformamide

生成物 1

HCID 86755725HCID 86755725、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

4N Hydrochloric acid--ethyl acetate solution (8.50 ml) was added to a solution of [[2-[(4-methylpiperazinyl)carbonyl]phenyl]methoxy]-N-octadecylformamide (11.98 g) in ethyl acetate (120 ml) while being cooled with ice. After being stirred for 30 minutes at room temperature, the reaction mixture was concentrated. The residue was recrystallized from ethyl acetate-ethanol mixed solvent, thereby yielding 12.12 g of the aimed compound as white solid.

後処理

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized from ethyl acetate-ethanol mixed solvent

出典と根拠

ORDレコード
ord-98ab8e0292ac4e08a1c2e69868fc2a70
出典データセット
uspto-grants-2000_09
特許番号
US06114325

反応ノート

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