Ammonia → 5-(Chloromethyl)isoxazole-3-carboxamide

Participants

Reaction Steps

Ammonia was passed into a solution of 10 g (55.56 mmol) of 5-chloromethylisoxazole-3-carbonyl chloride in 100 ml of methylene chloride at 10-15° C. for 1 h, and the mixture was then stirred at room temperature for 1 h. After the solution had been cooled to 0° C., the precipitate was filtered off with suction and washed with a little cold methylene chloride, and the residue was extracted by stirring with water twice to remove ammonium salts. Drying under reduced pressure resulted in 6.58 g of pure product as a pale powder (74% of theory).

Provenance & Evidence