HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Formyl-1-methyl-1H-pyrrole-2-carbonitrile → 4-(Aminomethyl)-1-methyl-1H-pyrrole-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Formyl-1-methyl-1H-pyrrole-2-carbonitrile | HCID 14173860 | — |
| Reactant | 5-(Aminomethyl)-1-methyl-1H-pyrrole-2-carbonitrile | HCID 22560012 | — |
| Reactant | 4-(azidomethyl)-1-methyl-1H-pyrrole-2-carbonitrile | HCID 22715993 | — |
| Product | 4-(Aminomethyl)-1-methyl-1H-pyrrole-2-carbonitrile | HCID 22715996 | — |
Reaction Steps
4-Aminomethyl-1-methylpyrrole-2-carbonitrile was prepared starting from 5-cyano-1-methylpyrrole-3-carbaldehyde similar to the synthesis of 5-aminomethyl-1-methylpyrrole-2-carbonitrile. However, the 4-azidomethyl-1-methylpyrrole-2-carbonitrile was advantageously reduced by a Staudinger reaction (see, for example, S. Nagarajan et al., J. Org. Chem. 52 (1987) 5044-6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114358 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-0b7164282a294d7d8b8c4773345d21ac |
| Source note | uspto-grants-2000_09 |