HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dibromopyridine → 2-Acetyl-6-bromopyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dibromopyridine | HCID 12274 | — |
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-Acetyl-6-bromopyridine | HCID 11298578 | — |
Reaction Steps
29.7 g of 2,6-dibromopyridine were reacted with 86.1 ml of n-butyllithium (1.6-molar solution in n-hexane) and 12 g of N,N-dimethylacetamide in 300 ml of diethyl ether as described in the literature [J. Organomet. Chem. 56 (1973), 53-66; Chem. Ber. 125 (1992), 1169-1190] to give 2-bromo-6-acetylpyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114363 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-f3e4b6f9576e42ffa83a428cb564c49e |
| Source note | uspto-grants-2000_09 |