HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-9-oxo-9,10-dihydroacridine-4-carboxylic acid → HCID 10847673, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-9-oxo-9,10-dihydroacridine-4-carboxylic acid | HCID 13763253 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 10847673 | HCID 10847673 | 90% |
Reaction Steps
Reduction of the known [Rewcastle and Denny, Synthesis, 1985, 217] 5-fluoro-9-oxoacridan-4-carboxylic acid as above gave 5-fluoroacridine-4-carboxylic acid (90%), mp (MeOH/H2O) 295-298° C. (dec). 1H NMR [(CD3)2SO] δ 7.74-7.80 (m, 1 H, ArH), 7.90-7.96 (m, 2 H, ArH), 8.19 (d, J=8.6 Hz, 1 H, ArH), 8.61 (dd, J=8.6, 1.2 Hz, 1 H. ArH), 8.81 (dd, J=7.0, 1.0 Hz, 1 H, ArH), 9.65 (s, 1 H, H-9). Anal. (C14H8FNO2) C, H, N, F.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114332 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-5f5956bc93654689a752b3ca0c33b351 |
| Source note | uspto-grants-2000_09 |