Benzenepropanal → HCID 54396813, compound

Participants

Reaction Steps

D-Serinamide (0.038 moles, 4 g) and 3-phenylpropanal (0.038 moles, 5.1 g) are dissolved in methanol (400 ml) in a Parr bottle and hydrogenated in the presence of 10% Pd/C (3 g) at 40 psi, until hydrogen absorption ceases. The catalyst is filtered off and the solution is evaporated to dryness under vacuum, taken up in ethyl acetate (300 ml) and washed with water (2×200 ml). The organic phase is dried and dissolved in warm ethyl ether (300 ml) to precipitate the product as a white solid by slow evaporation of the solvent at r.t. Yield: 3.8 g (45%)--m.p.=76-78° C. [α]589 (c=1, methanol)=+13.2°

Provenance & Evidence