HCID 70303967, compound → HCID 70304720, compound

HRID 1952967Notes

Reaction equation

HRID 1952967 reaction equation
[ClH:1].C(OC[C@H](NCCCC1C=CC=CC=1)C(N)=O)(=O)C.Cl.C(OC[C@H](NC1CC2C(=CC=CC=2)C1)C(N)=O)(=O)C.Cl.[C:42]([O:50][CH2:51][C@H:52]([NH:56][CH:57]1[CH2:65][C:64]2[C:59](=[CH:60][CH:61]=[CH:62][CH:63]=2)[CH2:58]1)[C:53]([NH2:55])=[O:54])(=[O:49])[C:43]1[CH:48]=CC=C[CH:44]=1>CO>[ClH:1].[CH2:58]1[C:59]2[C:64](=[CH:63][CH:62]=[CH:61][CH:60]=2)[CH2:65][CH:57]1[NH:56][C@@H:52]([CH2:51][O:50][C:42](=[O:49])[CH:43]([CH3:44])[CH3:48])[C:53]([NH2:55])=[O:54]

Participants

5

Reactant 3

HCID 70303967HCID 70303967, compoundHCID 70303968HCID 70303968, compoundHCID 70304214HCID 70304214, compound

Product 1

HCID 70304720HCID 70304720, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

With a similar procedure as described in the example 11 the following compounds were prepared: (S)-3-acetyloxy-2-(3-phenylpropylamino)propanamide hydrochloride (CHF 3023.01; compound n. 45); (S)-3-acetyloxy-2-(2-indanylamino)propanamide hydrochloride (CHF 3519.01; compound n. 74); [α]589 (c=1, methanol)=+29.8 (S)-3-benzoyloxy-2-(2-indanylamino)propanamide hydrochloride (CHF 3548.01; compound n. 78)

Workup

  1. customwere prepared

Sources & evidence

ORD record
ord-48449add0dfb4508891a0de568a2d382
Source dataset
uspto-grants-2000_09
Patent number
US06114391

Reaction notes

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