HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetamide → HCID 23302056, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetamide | HCID 6580 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5,6-dimethoxy-2,3-dihydro-1H-inden-2-amine | HCID 11041623 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 23302056 | HCID 23302056 | — |
Reaction Steps
5,6-Dimethoxy-2-indanylamine (0.024 moles, 4.6 g) and sodium bicarbonate (0.026 moles, 2.2 g) are added to a solution of chloroacetamide (0.024 moles, 2.2 g) in absolute ethanol (100 ml) and refluxed for 10 hours. The mixture is filtered at r.t. and the solution is evaporated to dryness. The resulting oil is chromatographed under medium pressure through silica gel (eluent: methylene chloride/methanol=90/10) Yield: 1.95 g (32.7%)--m.p.=135-138° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114391 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-fefa833ab59b44b6bcfbcf18620be3d7 |
| Source note | uspto-grants-2000_09 |