HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroethyl isocyanate → HCID 23301804, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroethyl isocyanate | HCID 16035 | — |
| Reactant | 4-(Aminomethyl)benzonitrile | HCID 82608 | — |
| Product | HCID 23301804 | HCID 23301804 | — |
Reaction Steps
The 4-cyanobenzenemethanamine obtainable by modified Gabriel synthesis, when reacted with chloroethylisocyanate, yields 1-[(4-cyanophenyl)methyl]-3-(2-chloroethyl)urea which when treated with potassium tert.butoxide in dimethylformamide is easily cyclised into the 1-[(4-cyanophenyl)methyl]-2-imidazo-lidinone; catalytic hydrogenation then leads to the desired 4-[(2-oxo-1-imidazolidinyl)methyl]benzenemethanamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114390 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-e9b4112477a74ecc92c24b840ff933b5 |
| Source note | uspto-grants-2000_09 |