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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1952990Generated: October 26, 2026

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → (R)-N5-[Amino(nitroimino)methyl]-N2-(diphenylacetyl)-N-[[4-(methylaminosulphonylmethyl)phenyl]methyl]-ornithinamide

https://huagongshe.com/reaction/1952990

Reaction equation

Participants

RoleNameHCIDCharge
ReactantO-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733207—
Reactant4-(Aminomethyl)-N-methylbenzenemethanesulfonamideHCID 9167425—
Reactant(R)-N5-[amino(nitroimino)methyl]-N2-(diphenylacetyl)-ornithineHCID 136381100—
Product(R)-N5-[Amino(nitroimino)methyl]-N2-(diphenylacetyl)-N-[[4-(methylaminosulphonylmethyl)phenyl]methyl]-ornithinamideHCID 13633368370%

Reaction Steps

Prepared analogously to Example 6d) from (R)-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine, 4-(methylamino-sulphonylmethyl)benzenemethanamine and TBTU in a yield of 70% of theory. Colourless amorphous substance.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06114390
Source datasetuspto-grants-2000_09
ORD IDord-85dd0bbb756244879b2a0c83dcea36ed
Source noteuspto-grants-2000_09