HRID1952997

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F

HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

HCID15480552

未命名化合物

结构：O=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)O)OCc1ccccc1

HCID54559825

未命名化合物

PRODUCTS

生成物

结构：NC(=O)Cc1ccc(CNC(=O)[C@@H](CCCNC(=O)OCc2ccccc2)NC(=O)C(c2ccccc2)c2ccccc2)cc1

HCID131721969

未命名化合物

收率 89%

PROCEDURE

实验过程

Prepared analogously to Example 6d) from (R)-N2 -diphenylacetyl-N5 -(phenylmethoxycarbonyl)-ornithine, 4-(aminocarbonylmethyl)-benzenemethanamine and TBTU in a yield of 89% of theory. Colourless crystals, Mp. 203-205° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0ceb0d0da2f944448a2c584eb70b7e81
来源数据集: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06114390
来源说明: uspto-grants-2000_09

反应 SMILES

[C:1]1([CH:7]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:8]([NH:10][C@@H:11]([C:26](O)=[O:27])[CH2:12][CH2:13][CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:35][C:36]([CH2:38][C:39]1[CH:44]=[CH:43][C:42]([CH2:45][NH2:46])=[CH:41][CH:40]=1)=[O:37].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[NH2:35][C:36]([CH2:38][C:39]1[CH:44]=[CH:43][C:42]([CH2:45][NH:46][C:26](=[O:27])[C@@H:11]([CH2:12][CH2:13][CH2:14][NH:15][C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])[NH:10][C:8](=[O:9])[CH:7]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:41][CH:40]=1)=[O:37]