HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → (R)-N-[[4-(aminocarbonylmethyl)phenyl]methyl]-N2-(diphenylacetyl)-ornithinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Methane | HCID 297 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | HCID 131721969 | HCID 131721969 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-N-[[4-(aminocarbonylmethyl)phenyl]methyl]-N2-(diphenylacetyl)-ornithinamide | HCID 67614787 | 82% |
Reaction Steps
Prepared analogously to Example 1d) but using a mixture of glacial acetic acid and ethanol (1/1, v/v) as solvent instead of methanol, from (R)-N-[[4-(aminocarbonylmethyl)phenyl]methyl]-N2 -(diphenylacetyl)-N5 -(phenylmethoxycarbonyl)-ornithinamide by catalytic hydrogenation in the presence of palladium on animal charcoal in a yield of 82% of theory. Colourless amorphous substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114390 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-d22255ef9daf47f7b03dc8f0b5ba2791 |
| Source note | uspto-grants-2000_09 |