Diisopropylethylamine → HCID 136333688, 화합물

참여 물질

반응 단계

A mixture of 0.53 g (0.997 mMol) of (R)-N5 -[amino(nitroimino)-methyl]-N-[[4-(aminomethyl)phenyl]methyl]-N2 -(diphenylacetyl)-ornithinamide, 0.16 g (1.08 mMol) of nitrobiuret, 50 ml of methanol and 0.2 ml of diisopropylethylamine was refluxed for 5 hours with stirring. The same amount of nitrobiuret and diisopropylethylamine was added again and the mixture was refluxed for a further 3 hours. The crystals obtained after leaving the mixture to stand for 14 hours at ambient temperature were suction filtered, washed thoroughly with methanol and diethylether and dried in vacuo. 0.51 g (83% of theory) of colourless crystals were obtained, Mp. 214-218° C.

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