Methanol → HCID 178476707, compound

Participants

Reaction Steps

Prepared analogously to Example 1d) from (R)-N-[[4-[[[amino-(cyanoimino)methyl]amino]methyl]phenyl]methyl]-N5 -[amino(nitroimino)methyl]-N2 -(diphenylacetyl)-ornithinamide by catalytic hydrogenation in the presence of palladium/activated charcoal and using methanol as solvent. After final purification by column chromatography on silica gel (Macherey-Nagel, 0.063-0.2 mm) using n-butanol/glacial acetic acid/water=4/1/1 (v/v/v) as eluant, the desired compound is obtained as a colourless, amorphous-glassy substance in a yield of 5.9% of theory.

Provenance & Evidence