HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → (R)-N-[[4-[2-(Aminocarbonyl)ethyl]phenyl]methyl]-N5-[amino(nitroimino)methyl]-N2-(diphenylacetyl)-ornithinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 23301859 | HCID 23301859 | — |
| Reactant | (R)-N5-[amino(nitroimino)methyl]-N2-(diphenylacetyl)-ornithine | HCID 136381100 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (R)-N-[[4-[2-(Aminocarbonyl)ethyl]phenyl]methyl]-N5-[amino(nitroimino)methyl]-N2-(diphenylacetyl)-ornithinamide | HCID 136333691 | 60% |
Reaction Steps
Prepared analogously to Example 4b) from (R)-N5 -[amino[nitroimino)methyl]-N2 -(diphenylacetyl)-ornithine, 4-[2-(aminocarbonyl)ethyl]benzenemethanamine and TBTU in a yield of 60% of theory. Colourless crystals, Mp. 139-140° C. (Acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114390 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-0688dc68c3ef4a69ad0f2bce642d6fa6 |
| Source note | uspto-grants-2000_09 |