Aluminium lithium hydride → HCID 23221166, compound

HRID 1953014Notes

Reaction equation

HRID 1953014 reaction equation
[C:1]1([CH2:7][N:8]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:17]([NH2:19])=O)[CH:14]=3)[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[C:1]1([CH2:7][N:8]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:17][NH2:19])[CH:14]=3)[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 23301829HCID 23301829, compound

Product 1

HCID 23221166HCID 23221166, compoundYield 74%

Procedure

Prepared analogously to Example 45b) from 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxamide by reduction with lithium aluminium hydride. The desired compound was obtained as a colourless oil in a yield of 74% of theory.

Sources & evidence

ORD record
ord-6f9e9391705245b98f7fe54cfca44b04
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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