O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 136333702, compound

HRID 1953023Notes

Reaction equation

HRID 1953023 reaction equation
[CH:1]1([C:4]2[N:8]([CH3:9])[C:7]3[CH:10]=[C:11]([C:15]([OH:17])=O)[CH:12]=[C:13]([CH3:14])[C:6]=3[N:5]=2)[CH2:3][CH2:2]1.Cl.[NH2:19][C:20]([NH:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][NH:31][C:32](=[O:45])[C@@H:33]([CH2:35][CH2:36][CH2:37][NH:38][C:39]([NH2:44])=[N:40][N+:41]([O-:43])=[O:42])[NH2:34])=[CH:26][CH:25]=1)=[O:21].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[NH2:19][C:20]([NH:22][CH2:23][C:24]1[CH:25]=[CH:26][C:27]([CH2:30][NH:31][C:32](=[O:45])[C@@H:33]([CH2:35][CH2:36][CH2:37][NH:38][C:39]([NH2:44])=[N:40][N+:41]([O-:43])=[O:42])[NH:34][C:15]([C:11]2[CH:12]=[C:13]([CH3:14])[C:6]3[N:5]=[C:4]([CH:1]4[CH2:2][CH2:3]4)[N:8]([CH3:9])[C:7]=3[CH:10]=2)=[O:17])=[CH:28][CH:29]=1)=[O:21]

Participants

4

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 23301993HCID 23301993, compoundHCID 136333697HCID 136333697, compound

Product 1

HCID 136333702HCID 136333702, compoundYield 51%

Procedure

Prepared analogously to Example 69a) from 2-cyclopropyl-1,4-dimethyl-1H-benzimidazole-6-carboxylic acid, (R)-N-[[4-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino)methyl]-ornithinamide-hydrochloride and TBTU in a yield of 51% of theory.

Sources & evidence

ORD record
ord-2b71a078ce144815af4d80970a1538f5
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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