O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 136333703, compound

HRID 1953026Notes

Reaction equation

HRID 1953026 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][C:17]([OH:19])=O)=[CH:8]1)=[O:5])[CH3:2].Cl.[NH2:21][C:22]([NH:24][CH2:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][NH:33][C:34](=[O:47])[C@@H:35]([CH2:37][CH2:38][CH2:39][NH:40][C:41]([NH2:46])=[N:42][N+:43]([O-:45])=[O:44])[NH2:36])=[CH:28][CH:27]=1)=[O:23].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[NH2:21][C:22]([NH:24][CH2:25][C:26]1[CH:27]=[CH:28][C:29]([CH2:32][NH:33][C:34](=[O:47])[C@@H:35]([CH2:37][CH2:38][CH2:39][NH:40][C:41]([NH2:46])=[N:42][N+:43]([O-:45])=[O:44])[NH:36][C:17](=[O:19])[CH2:16][C:9]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:7]([CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH:8]=2)=[CH:30][CH:31]=1)=[O:23]

Participants

4

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 23301812HCID 23301812, compoundHCID 136333697HCID 136333697, compound

Product 1

HCID 136333703HCID 136333703, compoundYield 56%

Procedure

Prepared analogously to Example 69a) from 1-(ethoxycarbonylmethyl)-1H-indole-3-acetic acid, (R)-N-[[4-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino)methyl]-ornithinamide-hydrochloride and TBTU in a yield of 56% of theory.

Sources & evidence

ORD record
ord-78dc8c93a21a47ae81685099fe3c3fc1
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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