O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate → HCID 136333704, compound

HRID 1953028Notes

Reaction equation

HRID 1953028 reaction equation
[CH2:1]([N:3]([CH2:20][CH3:21])[CH2:4][CH2:5][CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][C:17]([OH:19])=O)=[CH:8]1)[CH3:2].Cl.[NH2:23][C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][NH:35][C:36](=[O:49])[C@@H:37]([CH2:39][CH2:40][CH2:41][NH:42][C:43]([NH2:48])=[N:44][N+:45]([O-:47])=[O:46])[NH2:38])=[CH:30][CH:29]=1)=[O:25].CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F>>[NH2:23][C:24]([NH:26][CH2:27][C:28]1[CH:29]=[CH:30][C:31]([CH2:34][NH:35][C:36](=[O:49])[C@@H:37]([CH2:39][CH2:40][CH2:41][NH:42][C:43]([NH2:48])=[N:44][N+:45]([O-:47])=[O:46])[NH:38][C:17](=[O:19])[CH2:16][C:9]2[C:10]3[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:7]([CH2:6][CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:20][CH3:21])[CH:8]=2)=[CH:32][CH:33]=1)=[O:25]

Participants

4

Reactant 3

HCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 23301950HCID 23301950, compoundHCID 136333697HCID 136333697, compound

Product 1

HCID 136333704HCID 136333704, compoundYield 27%

Procedure

Prepared analogously to Example 69a) from 1-[3-(diethylamino)propyl]-1H-indole-3-acetic acid, (R)-N-[[4-(aminocarbonylaminomethyl)phenyl]methyl]-N5 -[amino(nitroimino)methyl]-ornithinamide-hydrochloride and TBTU in a yield of 27% of theory.

Sources & evidence

ORD record
ord-fd3fc99577b845d6b2f43195abec3a68
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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