HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 15895102, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | HCID 15895101 | HCID 15895101 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15895102 | HCID 15895102 | 81.4% |
Reaction Steps
Hydrogen chloride gas was bubbled for 3 minutes through a solution of (3S, 5R)-5-benzyloxycarbamoyl-3-(4-methoxyphenyl)-2-oxopyrrolidine-1-carboxylic acid tert-butyl ester (270 mg, 0.61 mmol) in methylene chloride (40 mL). After stirring for an additional 10 minutes, the solvent was evaporated to leave a white foam. The title compound (169 mg, 80%) was isolated by flash chromatography (eluting with ethyl acetate) and recrystallization from a mixture of ethyl acetate and hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06114361 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-a1b95408a95a4206bd51a20614f5ccbb |
| Source note | uspto-grants-2000_09 |