Sodium Iodide → HCID 22992850, compound

Participants

Reaction Steps

169 mg of the 4-(4-chlorobutyl)-3,8-dichloro-4,5-dihydro-1,4-benzoxazepin-5-one synthesized by the method of Example 17 described in International Publication WO96/24594 was dissolved in 3 ml of dimethylformamide, then 129 mg (1.5 equivalents) of 1-(2-pyridyl)piperadine, 158 mg (2 equivalents) of sodium iodide, and 106 mg (2 equivalents) of triethylamine were added and the resultant mixture agitated at 80° C. for 6 hours. This was treated and refined in the same way as Example 13 to obtain 219 mg of the above-referenced compound (yield 93%). Note that the dichloride was obtained by making a dichloride by an ordinary method, then recrystallizing from a mixed solvent of methanol, chloroform, and ether.

Provenance & Evidence