Sodium Iodide → HCID 131721977, compound

Participants

Reaction Steps

129 mg of the 3-chloro-4-(4-chlorobutyl)-4,5-dihydro-7-methyl-1,4-benzoxazepin-5-one synthesized by the method of Example 19 described in International Publication WO96/24594 was dissolved in 2 ml of dimethylformamide, then 106 mg (1.5 equivalents) of 1-(2-pyrimidinyl)piperadine, 129 mg (2 equivalents) of sodium iodide, and 87 mg (2 equivalents) of triethylamine were added and the resultant mixture agitated at 90° C. for 7 hours. This was then treated and purified in the same way as Example 13 to obtain 152 mg of the above-referenced compound (yield 83%). Note that the dichloride was obtained by making a dichloride by an ordinary method, then recrystallizing from ether.

Provenance & Evidence