Methanethiol → HCID 22621111, compound

Participants

Reaction Conditions

Reaction Steps

A solution of methanethiol (4 ml) in dry DMF was added to a mixture of ethyl -3-chloro-2-(N-ethyl-N-methylsulphonylamino)-4-fluorobenzoate (7.4 g) and anhydrous potassium carbonate (4.71 g) in DMF at 40° C. The mixture was maintained at -10° C. for 1 hour, then warmed to ambient temperature over 2.5 hours. Water was added and the mixture extracted with ether, washed with brine solution then water, dried (anhydrous magnesium sulphate) and the solvent evaporated to give ethyl 3-chloro-2-(N-ethyl-N-methylsulphonylamino)-4-(methylthio)benzoate (83 g) as a white powder, m.p. 109-110.5° C.

Provenance & Evidence