Dimethylamine → HCID 15888358, compound

Participants

Reaction Steps

To a cooled mixture of 3-bromo-1,2,4-thiadiazolo [4,5-a]benzimidazole (15.44 g, 0.0603 mole) in 100 mL dichloromethane, dimethylamine (40% solution in water) (5.44 g, 0.121 mole) was added dropwise. The reaction mixture was allowed to stir for 16 h at room temperature. It was then diluted with dichloromethane, washed with water, dried with sodium sulfate and evaporated under vacuum to give 10.47 g (80%) of 3-(dimethylamino)-1,2,4-thiadiazolo[4,5-a]benzimidazole as colourless crystals: mp 102-104° C.; 1H NMR (CDCl3)δ 7.74 (t, 2H), 7.41 (t, 1H), 7.27 (t, 1H), 3.06 (s, 6H) ppm. Anal. Calcd for C10H10N4S: C, 55.03;H, 4.62; N, 25.69. Found: C, 54.53;H, 4.90; N, 25.50.

Provenance & Evidence