Carbonocyanidic acid, methyl ester → HCID 23303087, compound

Participants

Reaction Steps

To a cooled solution of 2-butylimidazo[1,2-d]-1,2,4-thiadiazole-3(2H)-one (2.95 g, 15.0 mmole) in 25 mL dichloromethane, methyl cyanoformate (2.54 g, 30 mmole) was added dropwise and the mixture was stirred for 16 h at room temperature. The precipitate was filtered and subsequently washed with dichloromethane to give 2.18 g (80%w) of 3-(methoxycarbonyl)imidazo[1,2-d]-1,2,4-thiadiazole as colourless crystals: mp 164.5-165° C.; 1H NMR (CDCl3)δ 8.13 (s, 1H), 7.51 (s, 1H), 4.11 (s, 3H) ppm; IR (KBr)ν 3440, 1737, 1527, 1253, 1071 cm-1. Anal. Calcd for C6H5N3O2S: C, 39.34;H, 2.75; N, 22.94. Found: C, 39.41;H, 2.51; N, 22.94.

Provenance & Evidence