Cyanogen Bromide → HCID 15888359, compound

Participants

Reaction Steps

To a cooled solution of 2-butylimidazo[1,2-d]-1,2,4-thiadiazole-3(2H)-one (4.78 g, 0.0242 mole) in 25 mL dichloromethane, cyanogen bromide (5.13 g, 0.0482 mole) was added in one portion and the mixture was stirred for 16 h at room temperature. The precipitate was filtered, slurried in 10 mL of methanol and subsequently washed with dichloromethane to give 4.45 g (90%) of 3-bromoimidazo[1,2-d]-1,2,4-thiadiazole as a colourless powder: mp 220° C. (dec); MS in/z 205, 203 (M+). Anal. Calcd for C4H2N3SBr.circle-solid.1/2 H2O: C, 22.55;H, 1.42; N, 19.72; O, 3.75; S, 15.02; Br, 37.50. Found: Cf 22.79;H, 1.41; N, 19.42; O, 2.67; S, 14.61; Br, 38.20.

Provenance & Evidence