Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Ethylhexanoic Acid | HCID 8697 | — |
| Reactant | methyl (2S)-1-[(1S)-1-phenylethyl]azetidine-2-carboxylate | HCID 10998528 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | HCID 11687363 | HCID 11687363 | 400.8% |
Reaction Steps
To a mixture of methyl N-[(S)-methylbenzyl]azetidine-2-(s)-carboxylate (161.6 g) and water (323 g) was added 2-ethylhexanoic acid (116.9 g) and resulting mixture was stirred at 60° C. for about 12 hours. Heptane (161 g) was added to the reaction mixture and separated. The organic layer was extracted with water (80 g). Combined water layer was washed with heptane (161.6 g×3) to give aqueous N-[(S)-methylbenzyl]azetidine-2-(S)-carboxylic acid solution (606.2 g). Yield 94%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06114543 |
|---|
| Source dataset | uspto-grants-2000_09 |
|---|
| ORD ID | ord-b741fb9f74744ce796465f81515da351 |
|---|
| Source note | uspto-grants-2000_09 |
|---|
