Sodium Hydroxide → HCID 9825643, compound

HRID 1953245Notes

Reaction equation

HRID 1953245 reaction equation
Cl.[C:2]1([S:8]([NH:11][C:12]2[CH:36]=[CH:35][C:15]3[N:16]([CH2:29][C:30]([O:32]CC)=[O:31])[C:17]([CH2:19][C:20]4[CH:28]=[CH:27][C:23]([C:24]([NH2:26])=[NH:25])=[CH:22][CH:21]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:10])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[C:2]1([S:8]([NH:11][C:12]2[CH:36]=[CH:35][C:15]3[N:16]([CH2:29][C:30]([OH:32])=[O:31])[C:17]([CH2:19][C:20]4[CH:28]=[CH:27][C:23]([C:24]([NH2:26])=[NH:25])=[CH:22][CH:21]=4)=[N:18][C:14]=3[CH:13]=2)(=[O:10])=[O:9])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23302299HCID 23302299, compound

Product 1

HCID 9825643HCID 9825643, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

200 mg (0.379 mmol) of 4-[(5-benzenesulphonylamino-1-ethoxycarbonylmethyl-1H-benzimidazol-2-yl)-methyl]-benzamidine-hydrochloride are dissolved in 10 ml ethanol and stirred at 40° C. for 90 minutes after the addition of 1 ml 2N sodium hydroxide solution. The solvent is distilled off, the residue diluted with 20 ml water and acidified with glacial acetic acid. The precipitated product is suction filtered and dried.

Workup

  1. distillationThe solvent is distilled off
  2. additionthe residue diluted with 20 ml water
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-8a89faf17b994cf580c1de8d9a099b6e
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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