HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1953261Generated: October 31, 2026
Phosphorus pentachloride → 2-Chloro-1-methyl-5-nitro-1H-benzimidazole
https://huagongshe.com/reaction/1953261
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 1-Methyl-5-nitro-1,3-dihydro-2H-benzimidazol-2-one | HCID 606305 | — |
| Solvent | Phosphorus oxychloride | HCID 24813 | — |
| Product | 2-Chloro-1-methyl-5-nitro-1H-benzimidazole | HCID 10822391 | — |
Reaction Steps
2.1 g (0.01 mol) of phosphorus pentachloride are dissolved in 2.5 ml phosphorus oxychloride and after the addition of 1.9 g (0.01 mol) of 5-nitro-1-methyl-benzimidazol-2-one the mixture is stirred for two hours at 125° C. The solvent is evaporated off, the residue is poured onto ice water and neutralised with ammonia. The precipitate formed is suction filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06114532 |
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| Source dataset | uspto-grants-2000_09 |
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| ORD ID | ord-34226644c38e457ebf81005291fb39db |
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| Source note | uspto-grants-2000_09 |
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