Methanol → HCID 17910259, compound

Participants

Reaction Steps

4.9 g (0.015 mol) of [1-(4-methylamino-3-nitro-benzoyl)-cyclohexyl]-acetic acid are dissolved in 100 ml tetrahydrofuran and after the addition of 2.4 g (0.015 mol) of N,N'-carbonyldiimidazole the mixture is refluxed for 15 minutes. After concentration of the solution and addition of 30 ml methanol the mixture is refluxed for 3 hours. The solvent is distilled off, the residue chromatographed on silica gel and eluted with methylene chloride+methanol (1-5%). The desired fractions are combined and concentrated by evaporation.

Provenance & Evidence