Sodium Hydroxide → HCID 23302571, compound

HRID 1953276Notes

Reaction equation

HRID 1953276 reaction equation
[OH-].[Na+].Cl.C([O:6][C:7]([CH2:9][C:10]1([C:16]([C:18]2[CH:37]=[CH:36][C:21]3[N:22]([CH3:35])[C:23]([CH2:25][C:26]4[CH:34]=[CH:33][C:29]([C:30]([NH2:32])=[NH:31])=[CH:28][CH:27]=4)=[N:24][C:20]=3[CH:19]=2)=[O:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)=[O:8])C>O.C(O)C>[C:7]([CH2:9][C:10]1([C:16]([C:18]2[CH:37]=[CH:36][C:21]3[N:22]([CH3:35])[C:23]([CH2:25][C:26]4[CH:27]=[CH:28][C:29]([C:30]([NH2:32])=[NH:31])=[CH:33][CH:34]=4)=[N:24][C:20]=3[CH:19]=2)=[O:17])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]1)([OH:8])=[O:6]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 23302593HCID 23302593, compound

Product 1

HCID 23302571HCID 23302571, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 160 mg (4 mmol) of sodium hydroxide in 5 ml water and 20 ml ethanol are added 400 mg (0.8 mmol) of 4-[(5-(1-ethoxycarbonylmethyl-cyclohexan-1-yl-carbonyl)-1-methyl-1H-benzimidazol-2-yl)-methyl]-benzamidine-hydrochloride. After two hours at ambient temperature the solution is evaporated down, the residue is dissolved in water and acidified with glacial acetic acid. The precipitate is suction filtered and dried.

Workup

  1. customAfter two hours at ambient temperature the solution is evaporated down
  2. dissolutionthe residue is dissolved in water
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-7d024c6968d5421fa15c2d045edebee5
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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