Water → HCID 23302890, compound

HRID 1953286Notes

Reaction equation

HRID 1953286 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]([CH2:12][C:13]3[CH:20]=[CH:19][C:16]([C:17]#N)=[CH:15]C=3)=[N:9][C:8]=2[CH:21]=1)([O-])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+].O.[N:31]1C=CC=C[CH:32]=1>>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]2[S:11][C:10]([C:12]3[CH:13]=[CH:20][C:19]([C:32]#[N:31])=[C:16]([CH3:15])[CH:17]=3)=[N:9][C:8]=2[CH:21]=1

Participants

5

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 24489Sodium DithioniteHCID 23302495HCID 23302495, compound

Product 1

HCID 23302890HCID 23302890, compound

Conditions

Temperature
95 °C

Procedure

8.8 g (29.8 mmol) of 4-(5-nitro-benzothiazol-2-ylmethyl)-benzonitrile are dissolved in 300 ml pyridine, combined with 15.4 g sodium dithionite and 60 ml water at 50° C. and heated to 95° C. for 1 hour. The pyridine is distilled off, the residue is combined with ice water, the precipitated product is suction filtered and dried.

Workup

  1. distillationThe pyridine is distilled off
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-96d4570b5e3a491da5563d59c126fc80
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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