Potassium Nitrate → HCID 23302879, compound

HRID 1953288Notes

Reaction equation

HRID 1953288 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:11]1[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[C:13]([CH3:19])[CH:12]=1.[N+:20]([O-])([O-:22])=[O:21].[K+]>S(=O)(=O)(O)O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([N+:20]([O-:22])=[O:21])=[CH:8][CH:9]=2)[CH:4]=[C:3]1[C:11]1[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[C:13]([CH3:19])[CH:12]=1

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 23302506HCID 23302506, compound

Product 1

HCID 23302879HCID 23302879, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

6.9 g (28 mmol) of 4-(1-methyl-1H-indol-2-yl)-methyl-benzonitrile are placed in 50 ml conc. sulphuric acid. At 2° C. 2.9 g (28 mmol) of potassium nitrate are added batchwise, whereupon the temperature rises to 10° C. After 30 minutes at 2° C. the mixture is poured onto ice and the product precipitated is suction filtered, washed with ice water, dried and recrystallised from acetone.

Workup

  1. customAt 2° C
  2. customrises to 10° C
  3. additionAfter 30 minutes at 2° C. the mixture is poured onto ice
  4. customthe product precipitated
  5. filtrationfiltered
  6. washwashed with ice water
  7. customdried
  8. customrecrystallised from acetone

Sources & evidence

ORD record
ord-eb0aecdab1be4b7ca96bcf9c50e2a61c
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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