4-Nitrophenol → HCID 21250449, compound

Participants

Reaction Steps

To a solution of 12.6 g (90 mmol) of p-nitrophenol in 300 ml methylene chloride and 7.2 g (91 mmol) of pyridine, 14.2 g (99 mmol) of 1-chloroethyl chloroformate are added dropwise at -10° C. The solution is stirred for 72 hours at ambient temperature and then extracted with water and 0.5% sodium hydroxide solution. The combined organic extracts are dried and concentrated by evaporation. The residue is chromatographed on aluminium oxide and eluted with methylene chloride. The combined fractions are concentrated by evaporation, triturated with petroleum ether and suction filtered.

Provenance & Evidence