6-(Decyloxy)-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid → HCID 23297274, compound

Participants

Reaction Steps

0.34 g (8.95 mmol) of lithium aluminum hydride was added to 40 ml of ether. To this mixture was slowly added 2.54 g (7.65 mmol) of the 6-decyloxy-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid obtained in the first stage of Example 1. After the resulting mixture was stirred at room temperature for 30 minutes, it was heated under reflux for 6 hours. After cooling, the reaction mixture was caused to undergo hydrolysis and extraction with ether. The organic phase was concentrated and by purifying the concentrate using column chromatography there was obtained 2.31 g (7.26 mmol) of 6-decyloxy-1,2,3,4-tetrahydro-2-hydroxymethylnaphthalene as a white solid.

Provenance & Evidence