HCID 53855559, compound → HCID 54510275, compound

Participants

Reaction Steps

A mixture of 2.93 g (6.60 mmol) of the 4'-benzyloxy-4-biphenylcarboxylic acid (R)-1-trifluoromethyl-3-methoxypropyl ester obtained in the second stage and 0.4 g of 5% palladium/carbon as catalyst was added to 50 ml of THF. The solution was placed in a hydrogen atmosphere, using a hydrogen baloon, and was stirred at room temperature overnight. After filtering out the catalyst and concentrating the filtrate, there was obtained approximately quantitatively 4'-hydroxy-4-biphenylcarboxylic acid (R)-1-trifluoromethyl-3-methoxypropyl ester.

Provenance & Evidence