Tulobuterol → Acrylic Acid

Participants

Reaction Steps

2-Ethylhexyl acrylate (95 parts) and acrylic acid (5 parts) were polymerized in ethyl acetate under an inert gas atmosphere to give an acrylic adhesive solution. To this solution was added tulobuterol and isopropyl myristate as an additive so that their contents in the plaster layer were 20% and 30%, respectively, and the mixture was stirred well. As a crosslinking agent, a polyisocyanate compound (trademark CORONATE HL, manufactured by NIPPON POLYURETHANE INDUSTRY CO., LTD.) was added in a proportion of 0.15% of the acrylic adhesive, and the mixture was stirred thoroughly. This solution was cast onto a release liner so that the thickness after drying became 60 μm, and dried to give a plaster layer. Then, the plaster layer was adhered to a support [laminate film of a polyester nonwoven fabric (basic weight 12 g/m2) and 6 μm thick polyester film] on the nonwoven fabric side to give a percutaneous absorption type preparation of the present invention.

Provenance & Evidence