Sodium Hydroxide → HCID 15895950, compound

HRID 1953387Notes

Reaction equation

HRID 1953387 reaction equation
[CH3:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[C:8]2[C:3]=1[N:4]=[CH:5][CH:6]=[N:7]2.[OH-].[Na+]>C(O)C>[NH2:12][C:11]1[C:2]([CH3:1])=[C:3]2[C:8](=[CH:9][CH:10]=1)[N:7]=[CH:6][CH:5]=[N:4]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15895949HCID 15895949, compound

Product 1

HCID 15895950HCID 15895950, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5-methyl-6-nitroquinoxaline (1.4 g), ethanol (100 mL) and stannous chloride dihydrate (7.2 g) is heated at reflux for three hours, cooled to below room temperature in an ice bath and treated with 1.0 N NaOH solution (120 mL). The mixture is then extracted with chloroform (2×1000 mL). The combined extracts are dried over potassium carbonate, filtered, and rotary evaporated to give 6-amino-5-methylquinoxaline.

Workup

  1. temperatureis heated
  2. temperatureat reflux for three hours
  3. temperaturecooled to below room temperature in an ice bath
  4. extractionThe mixture is then extracted with chloroform (2×1000 mL)
  5. dry with materialThe combined extracts are dried over potassium carbonate
  6. filtrationfiltered
  7. customrotary evaporated

Sources & evidence

ORD record
ord-651f076f388c47d8a942f677acf839b4
Source dataset
uspto-grants-2000_09
Patent number
US06117871

Reaction notes

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