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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1953395Generated: November 1, 2026

tert-Butyl L-valinate → (S)-4-methyl-2-(phenoxathiine-2-sulfonylamino)-pentanoic acid

https://huagongshe.com/reaction/1953395

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl L-valinateHCID 114626—
Reactanttert-butyl (2S)-2-amino-4-methylpentanoateHCID 7022311—
ReactantThianthrene-2-sulfonyl chlorideHCID 15487617—
ReactantPhenoxathiine-2-sulfonyl chlorideHCID 15487618—
Product(S)-4-methyl-2-(phenoxathiine-2-sulfonylamino)-pentanoic acidHCID 9930463—

Reaction Steps

When in the procedure of Example 1, Step (b), thianthrene-2-sulfonyl chloride is replaced by phenoxathiine-2-sulfonyl chloride and (L)-valine-t-butyl ester is replaced with (L)-leucine-t-butyl ester, (S)-4-methyl-2-(phenoxathiine-2-sulfonylamino)-pentanoic acid is obtained; mp 120-130° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06117869
Source datasetuspto-grants-2000_09
ORD IDord-9dc02bb304834bfd8ee3770d8b00421d
Source noteuspto-grants-2000_09