HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitrostyrene → HCID 23298101, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitrostyrene | HCID 68514 | — |
| Reactant | 2-Acetamido-5-bromopyridine | HCID 293097 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Catalyst | Tetrabutylammonium Chloride | HCID 70681 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23298101 | HCID 23298101 | 90.3% |
Reaction Steps
A mixture of 3-nitrostyrene (7.0 g), 2-acetamido-5-bromopyridine (10.1 g), tetra-n-butylammonium chloride (13.1 g), palladium(II) acetate (0.08 g) and sodium bicarbonate (9.87 g) in N,N-dimethylformamide (70 ml) was stirred at 110pbC. for 6 hours. The reaction mixture was poured into ice-water and precipitated crystals were collected, washed with water and dried to give 3-[(E)-2-(6-acetamido-3-pyridyl)vinyl]nitrobenzene (12.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117875 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-b2e4fbccb6c34faebd40f2c3c2c38499 |
| Source note | uspto-grants-2000_09 |