Potassium Hydroxide → HCID 11601613, compound

Participants

Reaction Steps

Further, 1.43 g (4.6 mmol) of the ethyl 1-phenylsulfonylmethylcyclohexanecarboxylate and 1.52 g (23.0 mmol) of potassium hydroxide were dissolved in aqueous solution of 90% ethanol. After heating reflux for 18 hours, the reaction mixture was concentrated under reduced pressure. The obtained residue was dissolved in water and washed with ether. The resulting water layer was made acid (pH=2) by the addition of 4N-hydrochloric acid thereto and then extracted with ethyl acetate and washed with 1N-hydrochloric acid and saturated brine. The obtained organic layer was dried over anhyrous sodiumsulfate and concentrated under reduced pressure, whereby 1.22 g of the captioned 1-phenylsulfonylmethylcyclohexane-carboxylic acid was obtained in a yield of 60%.

Provenance & Evidence