HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boc-L-methioninol → (2RS,3S)-N-cyclopentyl-3-amino-2-hydroxy-5-(methylthio)pentanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boc-L-methioninol | HCID 10988238 | — |
| Reactant | (S)-tert-butyl 1-hydroxyhexan-2-ylcarbamate | HCID 13969856 | — |
| Product | (2RS,3S)-N-cyclopentyl-3-amino-2-hydroxy-5-(methylthio)pentanamide | HCID 53684029 | 42% |
Reaction Steps
The same reaction procedure as in Reference Example 12 was repeated except that (S)-2-[N-(2-methyl-2-propyloxycarbonyl)amino]hexanol used in Reference Example 12 was replaced by 7.53 g of (S)-2-[N-(2-methyl-2-propyloxycarbonyl) amino]-4-(methylthio)butanol, whereby 3.22 g of the captioned (2RS,3S)-N-cyclopentyl-3-amino-2-hydroxy-5-(methylthio)pentanamide was obtained in a yield of 42%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117870 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-6b3342bd5fdd458eaae0966cf7fcb9bf |
| Source note | uspto-grants-2000_09 |