HCID 56986282, compound → (2RS,3S)-2-hydroxy-3-[N-[1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarbonyl]amino]heptanoic acid

Participants

Reaction Steps

Further, to methanol 100 ml solution of 16.8 g (34 mmol) of the above phenylmethyl (2RS,3S)-2-hydroxy-3-[N-[1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarbonyl]amino]heptanoate, 1.5 g of 10% palladium carbon was added under haydrogen atmosphere and was stirred at the room temperature for two hours. After insoluble components of the reaction solution were removed by filtration, the filtrate was concentrated under reduced pressure, whereby 13.6 g of the captioned (2RS,3S)-2-hydroxy-3-[N-[1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarbonyl]amino]heptanoic acid was obtained in a yield of 68%.

Provenance & Evidence