1-(Morpholine-4-carboxamido)cyclohexanecarboxylic acid → N-[(S)-1-amino-1,2-dioxo-3-heptyl]-1-[N-[(2-methyl-2-propyloxycarbonyl)piperadine-4-carbonyl]amino]cyclohexanecarboxamide

Participants

Reaction Steps

The same reaction procedure as in Example 1 was repeated except that the 1-[N-(morpholine-4-carbonyl)amino]cyclohexanecarboxylic acid used in Example 1 was replaced by 1.06 g of 1-[N-[4-(2-methy-2-propyloxycarbonyl)piperadine-4-carbonyl]amino]cyclohexanecarboxylic acid, and (2RS,3S)-N-(2-methyl-2-propyl)-3-amino-2-hydroxyheptanamide used in Example 1 was replaced by 0.43 g of (2RS, 3S)-3-amino-2-hydroxyheptanamide synthesized in Reference Example 16, whereby 0.92 g of N-[(S)-1-amino-1,2-dioxo-3-heptyl]-1-[N-[(2-methyl-2-propyloxycarbonyl)piperadine-4-carbonyl]amino]cyclohexanecarboxamide was obtained in a yield of 63%.

Provenance & Evidence