4-Fluorophenol → HCID 15483748, compound

Participants

Reaction Steps

4-Bromomethyl-8-chloroquinoline (0.8 g, 3.11 mmol) was dissolved with stirring in dry THF (10 mls) and sodium hydride (0.15 g, 60% dispersion in mineral oil, 6.23 mmol) added. The mixture was stirred at room temperature for 15 minutes and 4-fluorophenol (0.52 g, 3.11 mmol) added. The mixture was stirred at room temperature overnight and worked up to provide the product (0.46 g, 51.2%) as a white solid, mp 144-5° C.

Provenance & Evidence