HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 7-Chloro-4-(3-trifluoromethylpyridine-2-yl)oxymethylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-3-(trifluoromethyl)pyridine | HCID 589833 | — |
| Reactant | (7-Chloroquinolin-4-yl)methanol | HCID 23298203 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-Chloro-4-(3-trifluoromethylpyridine-2-yl)oxymethylquinoline | HCID 23298195 | — |
Reaction Steps
4-Hydroxymethyl-7-chloroquinoline (0.6 g, 3.12 mmol) was dissolved with stirring in dry THF (20 mls) and sodium hydride (0.15 g, 60% dispersion in mineral oil, 3.75 mmol) added. The mixture was stirred at room temperature for one hour and 2-chloro-3-trifluoromethylpyridine (0.62 g, 3.42 mmol) added. The mixture was stirred overnight and worked up to provide the product (0.9 g, % as a tan solid, mp 125-7° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06117884 |
| Source dataset | uspto-grants-2000_09 |
| ORD ID | ord-f17d30380c6d476b9e07b56b148b7205 |
| Source note | uspto-grants-2000_09 |