Potassium Carbonate → HCID 15487472, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of potassium carbonate (45 mg) and 3-amino-4-(2-chloroethylsulfonyl)-1-ethyloxycarbonylmethyl-6-methyl-2-pyridinone (120 mg, 0.33 mmol) in dimethyl acetamide (1.0 mL) was stirred at 160° C. for 1 h. The reaction mixture was cooled and partitioned between ethyl acetate and dilute HCl. The organic layer was washed with brine, dried (Na2SO4) and evaporated to a semi-solid. The crude product was purified by flash column chromatography on silica gel (70-100% ethyl acetate/hexanes gradient) to give the title compound as a colorless crystalline solid:

Provenance & Evidence